By Jean-Louis Vincent (Ed.), Jean-Louis Vincent
The Yearbook compiles the newest advancements in experimental and scientific examine and perform in a single finished reference e-book. The chapters are written by means of good well-known specialists within the box of extensive care and emergency drugs. it's addressed to every body considering inner medication, anesthesia, surgical procedure, pediatrics, in depth care and emergency medicine.
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Additional info for Annual Update in Intensive Care and Emergency Medicine 2014
Two major sources exist via which iron can enter the bloodstream (Fig. 1). A small quantity of iron (approximately 1–2 mg per day) is taken up from duodenal enterocytes, which absorb iron from the gut. More importantly, most of the iron (20–25 mg per day) is recycled by macrophages of the reticuloendothelial system that retrieve iron from phagocytosed senescent red blood cells (RBCs) . Iron enters the cytosol of enterocytes and macrophages through divalent metal transporter 1 (DMT1), from where it can either be stored in ferritin, or gets exported through the iron exporter, ferroportin.
Review on Iron, Immunity and Intensive Care 21 Inflammation-induced Changes in Iron Homeostasis A profound change in body iron distribution is one of the key features of anemia of critical illness, diverting iron from the circulation to storage sites. Iron is shifted from the extracellular to the intracellular compartment as a result of inflammation by induction of hepcidin production in the liver. This leads to the subsequent internalization and degradation of ferroportin on iron exporting cells, especially macrophages of the reticuloendothelial system.
Pediatrics 130:e273–e280 14. Levy MM, Dellinger RP, Townsend SR et al (2010) The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med 38:367–374 15. Ninis N, Phillips C, Bailey L et al (2005) The role of healthcare delivery in the outcomes of meningococcal disease in children: case-control study of fatal and non-fatal cases. BMJ 330:1475 16. Santhanam I, Kissoon N, Kamath SR, Ranjit S, Ramesh J, Shankar J (2009) GAP between knowledge and skills for the implementation of the ACCM/PALS septic shock guidelines in India: is the bridge too far?
Annual Update in Intensive Care and Emergency Medicine 2014 by Jean-Louis Vincent (Ed.), Jean-Louis Vincent