By C. Wüster, T. Cowell
Complement factor: Hormone learn 2000, Vol. fifty four, No. 1
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Extra resources for Analytical Methods in Clinical Osteology: Useful Predictors of Long-Term Outcomes or a Waste of Time and Money? 4th Kigs Kims Expert Meeting on Growth ... Taormina, November (Hormone Research)
46 Antich P, Mason R, McColl R, Zerwech J, Pak C: Trabecular architecture studies by 3D MRI microscopy in bone biopsies. J Bone Miner Res 1994;9(suppl 1):327. 47 Kapadia RD, High W, Bertolini D, Sarkar SK: MR microscopy: A novel diagnostic tool in osteoporosis research. In Christiansen C (ed): 4th International Symposium on Osteoporosis & Consensus Development Conference, Hong Kong, 1993. New York, Reed Elsevier, 1993, p 28. 30 48 Simmons CA, Hipp JA: Method-based differences in the automated analysis of the threedimensional morphology of trabecular bone.
These mechanisms interact with bone in a way that no single kind of cell can. Modelling, rather than osteoblasts alone, provides nature’s main way of increasing bone strength, whereas BMU-based remodelling provides nature’s main way of conserving bone or removing bone that is not needed mechanically [15, 36, 37]. Directly or indirectly, special bone strain threshold ranges help to control both mechanisms [15, 36–39]. Where bone strains exceed the higher modelling threshold range (the minimum effective strain [MESm] range or equivalent stimulus), modelling is activated, increasing bone strength and ‘mass’.
J Bone Miner Res 1996;11:480–489. 25 Parfitt AM, Matthews C, Villanueva A: Relationships between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis. J Clin Invest 1983;72:1396– 1409. 26 Parfitt AM: The stereologic basis of bone histomorphometry. Theory of quantitative microscopy and reconstruction of the third dimension; in Recker R (ed): Bone Histomorphometry: Techniques and Interpretations. Boca Raton, CRC Press, 1983, pp 53–87. 27 Odgaard A, Gundersen HJG: Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions.
Analytical Methods in Clinical Osteology: Useful Predictors of Long-Term Outcomes or a Waste of Time and Money? 4th Kigs Kims Expert Meeting on Growth ... Taormina, November (Hormone Research) by C. Wüster, T. Cowell