By M. Balestrino
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Extra info for Advances in the Treatment of Ischemic Stroke
Mei, W. , & Ya, K. (2009). Hypothermia attenuates protective effects of ginkgolides on astrocytes from ischemia/reperfusion injury. Neurochemistry International, Vol. 55, No. 4, (December 2000), pp. , & Dingley, J. (2008). Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia. Stroke, Vol. 39, No. 4, (April 2008), pp. , & Maekawa, T. (2010). Moderate hypothermia suppresses jugular venous superoxide anion radical, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats.
Although the controversy in the use of magnesium and hypothermia in cerebral ischemia exists, a lot of experimental evidence demonstrates its efficacy in laboratory studies and it is necessary to perform more clinical trials to translate this combinatorial therapy to clinical 28 Advances in the Treatment of Ischemic Stroke use. , 2009). 3 Hypothermia and citicoline Hypothermia has been combined with other compounds. , 2000). Mild hypothermia combined with citicoline resulted in an additive effect in attenuating apoptosis in focal cerebral ischemia/reperfusion injury.
Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia. Proc Natl Acad Sci U S A, Vol. 100, No. 5, (March 2003), pp. 2906-10, ISSN 0027-8424 David, H. , Risso, J. , &Abraini, J. H. (2009). Post-ischemic helium provides neuroprotection in rats subjected to middle cerebral artery occlusion-induced ischemia by producing hypothermia. Journal of Cerebral Blood Flow & Metabolism, Vol. 29, No. 6, (June 2009), pp. A. (1999).
Advances in the Treatment of Ischemic Stroke by M. Balestrino