By Karsten Schrör
Written through a number one professional on Aspirin-related examine, this can be the main accomplished treatise at the pharmacological results and medical functions of 1 of the main winning medicinal drugs ever.
The textual content is written with a large viewers in brain, and to be comfortably comprehensible for clinicians, pharmacists, biomedical researchers and pharmacologists alike.
This moment, thoroughly revised version includes the newest result of scientific and pharmacological learn on Acetylsalicylic acid, addressing the a number of pharmacological homes of this well-known drug with a balanced view on their translation into scientific perform, together with prevention from cardiovascular ailments and colorectal cancer.
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Additional info for Acetylsalicylic acid
1997) Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. J. Biol. , 272 (34), 21181–21186. 22 Claria, J. N. (1995) Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell–leukocyte interactions. Proc. Natl. Acad. Sci. USA, 92 (21), 9475–9479. 23 Morris, T. et al. (2009) Effects of low-dose aspirin on acute inﬂammatory responses in humans. J. , 183 (3), 2089–2096. K. et al. (1991) Aspirin inhibits interleukin 1 induced prostaglandin H synthase expression in cultured endothelial cells.
1 History day. Unfortunately, he died himself in 1957, a year after publication of his last study, at the age of 74 years from a heart attack. It is not known from his records of whether or not he has fol lowed his own advices to take 1 aspirin tablet per day. One reason for not taking it could be that according to his opinion, aspirin had a bad bene ﬁt–risk proﬁle at the age of over 70 years – he had recommended the drug only for middle-aged (40–65 years) men . These studies of Craven were the ﬁrst to sug gest beneﬁcial effects of aspirin for prevention of myocardial infarction and stroke.
J. Pharmacol. Exp. , 117 (1), 39–51. E. (1977) Salicylate metabolism in twins: evidence suggesting a genetic inﬂuence and induction of salicylurate formation. J. Clin. , 60 (1), 32–42. W. (1964) Biochemical properties of anti-inﬂammatory drugs–III. Uncoupling of oxidative phosphorylation in a connective tissue (cartilage) and liver mitochondria by salicylate analogues: relationship of structure to activity. Biochem. , 13, 319–336. W. (1964) Uncoupling of oxidative phosphorylation by some arylacetic acids (anti inﬂammatory or hypercholesterolemic drugs).
Acetylsalicylic acid by Karsten Schrör